Mesothelioma is a dreadful disease, which doesn’t have a perfect cure. The affected person will show symptom only after a long period say, 20 years. Each year at least 3000 fresh cases of
mesothelioma is being identified in US.

The affected persons are being treated with different drug combinations especially symptomatically.

The drugs used for treating mesothelioma will reduce the number of platelets, which is an important substance in the blood for clotting. The reduction in the number of these cells will lead to profuse bleeding from even minor cuts or grazes.

Other important side effect of mesothelioma chemotherapy includes infertility. Some of the mesothelioma controlling drugs may stop ovulation or induce artificial menopause in the affected women.

The best-known side effect of mesothelioma chemotherapy is hair loss. This solely depends on the quantity of drug you are taking daily. The good news about this side effect is the hair will grow back after treatment has subsided.

In nut shell, the mesothelioma chemotherapy side effects include infertility in both men and women, reduce cells in bone marrow, loss of appeptite, diarrhea, and hair loss. Consult your health care provider if you exhibit any of these symptoms.

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If a patients health is too fragile for surgery or chemotherapy, radiation is often recommended. Radiation causes the fewest side effects and is usually easier to tolerate than
chemo. There are a few different forms of radiation therapy available to meso patients:

External beam radiation – the preferred type to treat mesothelioma, this type of radiation comes from a machine outside the body and is aimed toward affected areas. Usually administered 5-days-a-week for up to 5 weeks, this type of radiation is often used for palliative purposes – to lessen breathing difficulties, pain, bleeding, or difficulty swallowing – but seldom has much of an effect on the mesothelioma tumors. This type of radiation may also be used in addition to surgery.

Brachytherapy - Rarely prescribed for mesothelioma, this kind of radiation places radioactive material directly inside the lung or abdomen.

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The treatment program for mesothelioma depends on many factors, including: the stage of the cancer, where the cancer is, how far the cancer has spread, how the cancer cells
look under the microscope and the patient’s age and desires.
TIME MATTERS

People diagnosed with this disease are often told the expected survival rate is only eight to twelve months. However, specialists in treating malignant mesothelioma at the leading cancer centers often have better statistics.

For instance, the five-year survival rate has approached 40% for selected patients of Dr. David Sugarbaker at Brigham and Women’s Center in Boston. To qualify for Dr. Sugarbaker’s treatment you must meet certain criteria. One of them is being in the early stages of the disease, so time is of the essence. To find out more about Dr. Sugarbaker and other physicians and cancer centers specializing in mesothelioma click on Finding Specialists.

Keeping track of your medical treatment is useful and a personal medical records file can help.


TRADITIONAL CARE



There are three traditional kinds of treatment for patients with malignant mesothelioma:

* Surgery (taking out the cancer)
* Chemotherapy (using drugs to fight the cancer)
* Radiation Therapy (using high-dose x-rays or other high-energy rays to kill cancer cells)

Often two or more of these are combined in the course of treatment. (NEW! Click here for the newest trial of trimodal lung-sparing treatment for pleural mesothelioma: The Columbia Protocol.)


MESOMARK BLOOD TEST

In January 2007, the Food and Drug Administration (FDA) approved the MESOMARK assay to help monitor response to treatment in epithelial and bi-phasic malignant mesothelioma patients. A specific protein, or biomarker, called Soluble Mesothelin-Related Peptide (SMRP), may be released into the blood by mesothelioma cancer cells. By measuring the amount of SMRP in a blood sample, doctors may be able to better monitor a patient's progress. Based on the limited amount of data currently available, use of this test may be beneficial, but effectiveness has not been determined at this time. The MESOMARK blood test has NOT yet been approved for the early diagnosis of mesothelioma.

This test has been approved as a Humanitarian Use Device (HUD), meaning that physicians must follow certain procedures to qualify their patients for testing. Once the physician is certified, informational brochures will be sent to be distributed to each applicable patient.

Those wishing to take part in

MESOMARK testing will be asked to provide one or more samples of blood. The blood samples will then be sent to a national reference laboratory for testing. In conjunction with other clinical and laboratory data obtained by your doctor, decisions regarding your treatment and care may be simplified. You may discontinue testing at any time.

The costs associated with the MESOMARK blood test may not be covered under health insurance, therefore, you may be required to pay all or part of the costs out of pocket. It is recommended that you check with your insurance carrier to determine whether coverage is available under your policy.

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There are more treatment possibilities for Mesothelioma cancer than surgery, chemotherapy and radiation therapy: the clinical trials. They offer no only benefits, but also risks that cancer patients should know before taking part in one of these research studies.

The U.S. National Cancer Institute sponsors clinical trials, because Mesothelioma cancer is difficult to control. This research is being performed to find out new treatments and better ways to use the current medical procedures.

Clinical trials are performed before the application of any new treatment in human beings, because doctors should know if the treatment is safe for their patients and effective to fight the disease on the stage level in which is.

Patients with mesothelioma can participate in research programs as a treatment option, because the possibility exists in the United States. People interested in take part in a clinical trial, however, should talk with their doctors before.

There is information about clinical trials in the Cancer Information Service (CIS) of the above mentioned Institute or may call to the toll-free phone number 1–800–4–CANCER to talk to CIS staff who may identify and provide detailed information about specific ongoing clinical trials.

The Web have various information about the subject, such as basic trial information, trial description with a summary and the eligibility criteria, and trial sites and contacts in the U.S.

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Cancer is one of the most fatal diseases nowadays. It doesn’t choose its victims. Men and women alike, old and young die of cancer. Mesothelioma is a rare form of cancer that affects the mesothelium,
specifically the Pleura (membrane that surrounds the lungs) and the Peritoneum (membrane surrounding the abdomen). Both Pleural Mesothelioma and Peritoneum Mesothelioma are primarily caused by the inhalation or exposure to asbestos, an incombustible fibrous mineral of impure magnesium silicate used in various industrial products. About 30 to 50 per cent of the total Mesothelioma cancer patients had not been exposed to asbestos, yet they have acquired the disease. Cancer specialists continue to study this rare kind of cancer so as to provide the public clear and exact information with regard to its cause, nature and cure.

Like many other forms of cancer, Mesothelioma has different stages. The earliest stage is still curable since only one layer of the pleura is affected. Surgery is the number one option for patients with Stage I Mesothelioma. The doctor removes the part of the lining of the lungs or chest (in case of Pleural Mesothelioma) and the lining of the abdomen (in case of Peritoneal Mesothelioma). In Stage II Mesothelioma, surgery can still be executed although some lymph nodes may have already been infected by the malignant Mesothelioma cancer cells. The diaphragm may also be removed; in severe cases, the Mesothelioma patient has to sacrifice one of his lungs.

Usually, surgery comes with systemic treatments, which include radiotherapy and chemotherapy. Through radiotherapy, Mesothelioma cancer cells are killed; however, only the cells in the treated area die. High energy rays used in radiotherapy or radiation therapy may either come from an external machine or from thin plastic tubes positioned into the tissues where Mesothelioma cancer-stricken cells are found. Inside the plastic tubes are radiation-emitting materials that kill the malignant cells. The use of an external machine is called external radiation therapy while the other is called internal radiation therapy. Also, a radioactive substance such as radiolabeled monoclonal antibody is circulated around the body during radiotherapy.

Chemotherapy is the use of anti-cancer drugs to kill the malignant cells. In treating Mesothelioma, the anti-cancer drugs are usually given to the patient through intravenous injection (within the vein). Oncologists are still studying the possibility of treating Mesothelioma through intracavitary chemotherapy (within the chest or abdomen). Some Mesothelioma patients also undergo Photodynamic therapy, a kind of cancer therapy that combines the use of drug (photosensitizer) with a specific kind of light. The photosensitizing agent when exposed to the light produce oxygen that destroys nearby malignant cancer cells. The drug is injected into the bloodstream and is absorbed by the cells.

In order to relieve the symptoms of Mesothelioma such as the pain in the chest or abdomen due to the build up of fluid, a physician drains the fluid by using a needle. The procedure is known as thoracentesis (removal of fluid in the chest) or paracentesis (removal of the fluid in the abdomen). To prevent further accumulation of the lubricating fluid in the membranes of the chest or abdomen, drugs are given through a tube in the affected organ.

Although the said treatments to Mesothelioma have been proven effective, chance of recovery and survival still depends on the size or extent of the cancer. Chances are higher when Mesothelioma is still in its early stages. Surgery is only advisable only up to the second stage of the Mesothelioma cancer wherein only one part or smaller portions of the membranes are affected. A patient diagnosed with stage IV Mesothelioma (diffuse Mesothelioma) has only about 4-24 months to live. Furthermore, the age of the patient and his general health condition is also crucial to his recovery. Older patients do not respond well to certain cancer treatments such as surgery because their tissues, organs and other body parts are more delicate.

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Mesothelioma cancer is currently treated through three treatments, depending on the cancer location, the disease stage, and the patient's general health and age. These treatments are surgery, chemotherapy and radiation therapy, which sometimes are combined to fight the disease in so far as possible.

In a surgery, one of the most common treatments for mesothelioma, the doctor removes part of the lining of the abdomen or the chest and some tissue around it. In a pneumonectomy, the doctor may also remove one lung when the patient has pleural mesothelioma or cancer of the pleura. In other surgical procedure, the doctor may also remove part of the diaphragm, the muscle below the lungs that helps with breathing.

Through these procedures, the medical specialist shall try to excise tumourous tissue arising from this cancer disease. As these operations will reduce the patient's respiratory capacity, the surgeon will evaluate the patient's ability to function after a lung tissue removal, before performing a pneumonectomy.

Another method to fight Mesothelioma is chemotherapy or the use of anticancer drugs to kill cancer cells throughout the body. These drugs are given to the patient by an intravenous procedure, an injection into a vein. Currently, experts are studying the effectiveness of intracavitary chemotherapy or the possibility of giving chemotherapy straight to the chest or abdomen.

Radiotherapy or radiation therapy is the use of high-energy rays to destroy malignant cells and shrink tumors. It is important to know that this medical procedure attacks the cancer cells only in the treated area. There are two ways of giving this therapy. One, external radiation, in which the radiation comes from a machine, and other, internal radiation, where the cancer cells are found after putting materials that produce radiation into the affected area.

Doctor's way to relieve patient's pain is to use a needle or a thin tube to drain fluid that has built up in the abdominal or chest cavities through a procedure called thoracentesis, when it is from the chest, and paracentesis, when the removal is from the abdomen. The specialists may also give the drugs through a tube in the chest to prevent the accumulation of more liquid.

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Mesothelioma is a kind of permanent cancer disease. Mesothelioma cancer occurs when tissues of our lungs or abdominal components get affected. In more cases asbestos exposure was identified as the reason for mesothelioma disease.
Symptoms of mesothelioma may not appear immediately after it’s exposure, it takes time between twenty to thirty years. This enables the disease identification process a critical one.

Treatments for mesothelioma depends on the stage of the cancer, the specific part being affected, the total amount of space being affected, how long one have the problem, the look of the cancer cells under microscope and the age factor of the patient. These are the factors that are being considered before choosing the treatment option.

Treatments for mesothelioma include Surgery, Chemotherapy and Radiation Therapy.

Surgery: There are two types of surgeries available one is aggressive surgery and another one is called palliative procedures.

Aggressive surgery is done through a procedure named extra pleural pneumonectomy, by which the pleura, the lung, the diaphragm and the pericardium are removed. The aggressive surgery’s motive is to remove as much mesothelioma tumor as possible.

Palliative procedures will be done when the mesothelioma disease is at the matured stage. The motive of this procedure is to give relief to the patient from the symptoms.

Chemotherapy: In chemotherapy drugs are being used to treat mesothelioma cancer. The drugs may be in the form of pills or injections. To improve the results of chemotherapy some drugs may be used as mix in some proportion and this has given a good improvement in the treatment results.

Radiation therapy: Radiation therapy uses radiations to kill mesothelioma tumor. This procedure is complex to undergo as the tumors are surrounded by sensitive parts of our body. There are possibilities that the heart and lungs being damaged by the radiation. Lower dose radiation is one solution to slightly overcome from this critical issue.

Though mesothelioma is a permanent cancer disease and the survival rate is very low, timely identification and perfect treatme

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Clinical research to treat malignant mesothelioma is very active and although no treatment has yet proved entirely successful, there exist a range of treatments available to individuals diagnosed with the disease.
There are three types of standard treatments used to treat malignant mesothelioma which include: surgery, radiation therapy, and chemotherapy.

Surgery

Surgery for malignant mesothelioma is divided into a number of sub-classes, which are specially designed to limit the disease for individuals with particular strains of the disease.

Extrapleural pneumonectomy is a severe form of surgery in which the entire lung and a portion of the lining of the chest, the diaphragm, and some or the entire sac which surrounds the heart is removed.

Wide local excision is a form of surgery which targets and removes the cancer and a limited amount of the healthy tissue surrounding the cancerous region.

Pleurectomy and decortication removes part of the covering of the lungs, as well as the lining of the chest and portions of the outside covering of the lungs.

The surgical procedure pleurodesis is a distinct technique insofar as it employs a blend of chemicals and/or drugs to create an intentional scar between the layers of the pleura. Post surgery, the space created by the scar must be drained, using either a catheter or chest tube, and is then filled with a chemical which inhibits the accumulation of fluid in the pleura cavity.

Radiation

The second primary medical technique used to fight the development of malignant mesothelioma is radiation. Radiation therapy, as applied to malignant mesothelioma uses the same basic technology as other forms of medical radiation insofar as the technique employs high energy x-rays to kill cancer cells. The process is divided into two broad categories:

External radiation therapy is a technique in which a machine sends radiation in a targeted stream at a certain portion of the body, and in so doing it kills the cancerous cells in its purview.

Internal radiation therapy, by contrast, uses not an external machine, but rather needles, seeds and catheters to place radioactive substance directly on or near the cancer. While the precise method of implementation will of course depend upon the type and stage of the illness, what is constant within this category is that the goal is to get the radiation placed directly onto the cancerous area and in so doing provide a more concentrated and directed dosage.

Chemotherapy

The third standard malignant mesothelioma treatment is Chemotherapy. Chemotherapy uses drugs which target cancer cells and stop them from dividing and thus prevent their growth.

In systemic chemotherapy, the drug can be taken by mouth or injected, but either way the goal is to have it reach cancer cells by means of the body’s own blood circulation system. In regional chemotherapy, the drug is placed directly onto the target area. And finally, combination chemotherapy involves the use of two or more anticancer drugs which can be administered either orally or through injection.

Malignant mesothelioma is a difficult disease for anyone to bear, however, educating oneself as to the options available is an important step for making the process more manageable.

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